Most leader jerseys
| Pos. | Rider | #Leader jerseys | Date of first jersey |
|---|---|---|---|
| 1 | Bottecchia Ottavio | 32 | 1923-06-26 |
| 2 | Bartali Gino | 21 | 1937-07-07 |
| 3 | Gimondi Felice | 19 | 1965-06-24 |
| 4 | Nibali Vincenzo | 18 | 2014-07-06 |
| 5 | Coppi Fausto | 17 | 1949-07-19 |
| 6 | Nencini Gastone | 13 | 1960-06-26 |
| 7 | Magni Fiorenzo | 9 | 1949-07-10 |
| 8 | Chiappucci Claudio | 8 | 1990-07-12 |
| 9 | Nocentini Rinaldo | 8 | 2009-07-10 |
| 10 | Moser Francesco | 7 | 1975-06-26 |
| 11 | Guerra Learco | 7 | 1930-07-03 |
| 12 | Zilioli Italo | 6 | 1970-06-28 |
| 13 | Cipollini Mario | 6 | 1993-07-07 |
| 14 | Favero Vito | 6 | 1958-07-09 |
| 15 | Pantani Marco | 5 | 1998-07-27 |
| 16 | Elli Alberto | 4 | 2000-07-06 |
| 17 | Di Paco Raffaele | 4 | 1931-07-03 |
| 18 | Vanzella Flavio | 2 | 1994-07-06 |
| 19 | Gotti Ivan | 2 | 1995-07-05 |
| 20 | Aru Fabio | 2 | 2017-07-13 |
| 21 | Ronconi Aldo | 2 | 1947-07-02 |
| 22 | Ciccone Giulio | 2 | 2019-07-11 |
| 23 | De Pra Tommaso | 1 | 1966-06-30 |
| 24 | Bontempi Guido | 1 | 1988-07-03 |
| 25 | Polidori Giancarlo | 1 | 1967-07-02 |
| 26 | Borgarello Vincenzo | 1 | 1912-07-02 |
| 27 | Carrea Andrea | 1 | 1952-07-03 |
| 28 | Biagioni Serafino | 1 | 1951-07-08 |
| 29 | Micheletto Giovanni | 1 | 1913-06-29 |