| Pos. | Edition | Number of different leaders | Leaders |
|---|
| 1 | 2011 | 9 | Froome, Wiggins, Cobo, Rodríguez, Fuglsang, Chavanel, Lastras, Bennati, Mollema |
| 2 | 2008 | 8 | Contador, Martínez, Leipheimer, Pozzato, Chavanel, Bennati, Ballan, Valverde |
| 3 | 1960 | 7 | Barrutia, Desmet, Mulder, Mas, Manzaneque, Alberdi, Galdeano |
| 4 | 1964 | 7 | Jiménez, Looy, Vélez, Otaño, Sels, Poulidor, Pérez |
| 5 | 1967 | 7 | Ducasse, Janssen, Reybrouck, Uriona, Perurena, Dancelli, López |
| 6 | 1957 | 6 | Chacon, Moreno, Morales, Botella, Loroño, Bahamontes |
| 7 | 1958 | 6 | Herrero, Pacheco, Stablinski, Groot, Couvreur, Looy |
| 8 | 1959 | 6 | Looy, Vloebergs, Suarez, Segu, Karmany, Everaert |
| 9 | 1961 | 6 | Vélez, Soler, Seynaeve, Mahé, Messelis, Talamillo |
| 10 | 1966 | 6 | Momene, Gabica, Sivilotti, Uriona, Haast, Errandonea |
| 11 | 1968 | 6 | Gimondi, Martín, Wright, Janssen, Pérez, Altig |
| 12 | 1969 | 6 | Steegmans, Pingeon, Ocaña, Sgarbozza, Wright, Saéz |
| 13 | 1976 | 6 | Pesarrodona, Thurau, Kuiper, Elorriaga, Cauwer, Agostinho |
| 14 | 1983 | 6 | Pino, Gaigne, Hinault, Lejarreta, Fernández, Gorospe |
| 15 | 1989 | 6 | Brabant, Delgado, Farfán, Lameire, Leclerc, Hernandez |
| 16 | 2006 | 6 | Vinokourov, Hushovd, Brajkovič, Luca, Sastre, Valverde |
| 17 | 2016 | 6 | Kwiatkowski, Kennaugh, Fernández, Cruz, Quintana, Atapuma |
| 18 | 1946 | 5 | Olmos, Costa, Martín, Rodríguez, Langarica |
| 19 | 1955 | 5 | Loroño, Dotto, Geminiani, Marigil, Bauvin |
| 20 | 1971 | 5 | Perurena, Pijnen, Tamames, Lasa, Bracke |
| 21 | 1985 | 5 | Ruiz, Millar, Indurain, Oosterbosch, Delgado |
| 22 | 1986 | 5 | Blanco, Millar, Marie, Gomez, Pino |
| 23 | 1987 | 5 | Herrera, Vandenbroucke, Pagnin, Kelly, Dietzen |
| 24 | 1997 | 5 | Zülle, Guidi, Dufaux, Jalabert, Michaelsen |
| 25 | 1998 | 5 | Zberg, Jalabert, Jiménez, Guidi, Olano |
| 26 | 1999 | 5 | Olano, Ullrich, Durand, Wüst, Gonzalez De Galdeano |
| 27 | 2000 | 5 | Casero, González, Zülle, Olano, Heras |
| 28 | 2001 | 5 | Botero, Casero, Sevilla, Beloki, Millar |
| 29 | 2002 | 5 | González, Sevilla, Heras, Zarrabeitia, Beloki |
| 30 | 2004 | 5 | Joachim, Heeswijk, Landis, Beltrán, Heras |
| 31 | 2007 | 5 | Efimkin, Devolder, Freire, Menchov, Bennati |
| 32 | 2010 | 5 | Gilbert, Cavendish, Rodríguez, Nibali, Antón |
| 33 | 2013 | 5 | Horner, Roche, Nibali, Moreno, Brajkovič |
| 34 | 2014 | 5 | Castroviejo, Matthews, Contador, Valverde, Quintana |
| 35 | 2015 | 5 | Velits, Dumoulin, Aru, Rodríguez, Chaves |
| 36 | 2018 | 5 | Yates, Herrada, Dennis, Kwiatkowski, Molard |
| 37 | 1948 | 4 | Ruiz, Gielen, Langarica, Berrendero |
| 38 | 1970 | 4 | Tamames, Ocaña, Perurena, Pijnen |
| 39 | 1972 | 4 | Perurena, Pijnen, Fuente, Lasa |
| 40 | 1974 | 4 | Perurena, Thévenet, Fuente, Swerts |
| 41 | 1975 | 4 | Tamames, Lasa, Perurena, Swerts |
| 42 | 1982 | 4 | Lejarreta, Gomez, Criquielion, Arroyo |
| 43 | 1988 | 4 | Fuerte, Kelly, Cubino, Pastorelli |
| 44 | 1990 | 4 | Ruiz, Klimov, Gorospe, Giovannetti |
| 45 | 1992 | 4 | Ruiz, Montoya, Rominger, Nijdam |
| 46 | 1996 | 4 | Conte, Zülle, Jalabert, Baldato |
| 47 | 2003 | 4 | Gonzalez De Galdeano, Rodríguez, Heras, Nozal |
| 48 | 2009 | 4 | Cancellara, Evans, Valverde, Greipel |
| 49 | 2012 | 4 | Contador, Castroviejo, Rodríguez, Valverde |
| 50 | 1935 | 3 | Escuriet, Deloor, Dignef |
| 51 | 1941 | 3 | Berrendero, Rodríguez, Trueba |
| 52 | 1947 | 3 | Costa, Rodríguez, Dijck |
| 53 | 1962 | 3 | Elliott, Barrutia, Altig |
| 54 | 1965 | 3 | Looy, Wolfshohl, Poulidor |
| 55 | 1973 | 3 | Merckx, Karstens, Pesarrodona |
| 56 | 1984 | 3 | Delgado, Moser, Caritoux |
| 57 | 1991 | 3 | Fuerte, Diaz, Mauri |
| 58 | 1995 | 3 | Jalabert, Pianegonda, Olano |
| 59 | 2005 | 3 | McGee, Menchov, Heras |
| 60 | 2017 | 3 | Dennis, Froome, Lampaert |
| 61 | 1936 | 2 | Deloor, Huts |
| 62 | 1945 | 2 | Rodríguez, Berrendero |
| 63 | 1950 | 2 | Rodríguez, Braeckeveldt |
| 64 | 1956 | 2 | Steenbergen, Conterno |
| 65 | 1963 | 2 | Barrutia, Anquetil |
| 66 | 1978 | 2 | Haute, Hinault |
| 67 | 1979 | 2 | Zoetemelk, Levavasseur |
| 68 | 1980 | 2 | Visentini, Rupérez |
| 69 | 1981 | 2 | Battaglin, Clère |
| 70 | 1993 | 2 | Rominger, Zülle |
| 71 | 1942 | 1 | Berrendero |
| 72 | 1977 | 1 | Maertens |
| 73 | 1994 | 1 | Rominger |
