| Pos. | Edition | Number of different leaders | Leaders |
|---|
| 1 | 2011 | 9 | Chavanel, Lastras, Bennati, Mollema, Froome, Wiggins, Cobo, Rodríguez, Fuglsang |
| 2 | 2008 | 8 | Bennati, Ballan, Valverde, Contador, Martinez, Leipheimer, Pozzato, Chavanel |
| 3 | 1960 | 7 | Manzaneque, Alberdi, Galdeano, Barrutia, Desmet, Mulder, Mas |
| 4 | 1964 | 7 | Otaño, Sels, Poulidor, Pérez, Jiménez, Looy, Vélez |
| 5 | 1967 | 7 | Perurena, Dancelli, López, Ducasse, Janssen, Reybrouck, Uriona |
| 6 | 1957 | 6 | Botella, Loroño, Bahamontes, Chacon, Moreno, Morales |
| 7 | 1958 | 6 | Groot, Couvreur, Looy, Herrero, Pacheco, Stablinski |
| 8 | 1959 | 6 | Karmany, Everaert, Looy, Vloebergs, Suarez, Segu |
| 9 | 1961 | 6 | Mahé, Messelis, Talamillo, Vélez, Soler, Seynaeve |
| 10 | 1966 | 6 | Haast, Errandonea, Momene, Gabica, Sivilotti, Uriona |
| 11 | 1968 | 6 | Pérez, Altig, Gimondi, Martín, Wright, Janssen |
| 12 | 1969 | 6 | Ocaña, Sgarbozza, Wright, Saéz, Steegmans, Pingeon |
| 13 | 1976 | 6 | Cauwer, Agostinho, Pesarrodona, Thurau, Kuiper, Elorriaga |
| 14 | 1983 | 6 | Lejarreta, Fernández, Gorospe, Pino, Gaigne, Hinault |
| 15 | 1989 | 6 | Leclerc, Hernandez, Brabant, Delgado, Farfán, Lameire |
| 16 | 2006 | 6 | Brajkovič, Luca, Sastre, Valverde, Vinokourov, Hushovd |
| 17 | 2016 | 6 | Quintana, Atapuma, Kwiatkowski, Kennaugh, Fernández, Cruz |
| 18 | 1946 | 5 | Rodríguez, Langarica, Olmos, Costa, Martín |
| 19 | 1955 | 5 | Marigil, Bauvin, Loroño, Dotto, Geminiani |
| 20 | 1971 | 5 | Lasa, Bracke, Perurena, Pijnen, Tamames |
| 21 | 1985 | 5 | Oosterbosch, Delgado, Ruiz, Millar, Indurain |
| 22 | 1986 | 5 | Gomez, Pino, Blanco, Millar, Marie |
| 23 | 1987 | 5 | Pagnin, Kelly, Dietzen, Herrera, Vandenbroucke |
| 24 | 1997 | 5 | Jalabert, Michaelsen, Zülle, Guidi, Dufaux |
| 25 | 1998 | 5 | Guidi, Olano, Zberg, Jalabert, Jimenez |
| 26 | 1999 | 5 | Wüst, Gonzalez De Galdeano, Olano, Ullrich, Durand |
| 27 | 2000 | 5 | Olano, Heras, Casero, Gonzalez, Zülle |
| 28 | 2001 | 5 | Beloki, Millar, Botero, Casero, Sevilla |
| 29 | 2002 | 5 | Zarrabeitia, Beloki, Gonzalez Jimenez, Sevilla, Heras |
| 30 | 2004 | 5 | Landis, Beltran, Heras, Joachim, Heeswijk |
| 31 | 2007 | 5 | Menchov, Bennati, Efimkin, Devolder, Freire |
| 32 | 2010 | 5 | Nibali, Anton, Gilbert, Cavendish, Rodríguez |
| 33 | 2013 | 5 | Moreno, Brajkovič, Horner, Roche, Nibali |
| 34 | 2014 | 5 | Valverde, Quintana, Castroviejo, Matthews, Contador |
| 35 | 2015 | 5 | Rodríguez, Chaves, Velits, Dumoulin, Aru |
| 36 | 1948 | 4 | Berrendero, Ruiz, Gielen, Langarica |
| 37 | 1970 | 4 | Perurena, Pijnen, Tamames, Ocaña |
| 38 | 1972 | 4 | Lasa, Perurena, Pijnen, Fuente |
| 39 | 1974 | 4 | Fuente, Swerts, Perurena, Thévenet |
| 40 | 1975 | 4 | Perurena, Swerts, Tamames, Lasa |
| 41 | 1982 | 4 | Arroyo, Lejarreta, Gomez, Criquielion |
| 42 | 1988 | 4 | Cubino, Pastorelli, Fuerte, Kelly |
| 43 | 1990 | 4 | Gorospe, Giovannetti, Ruiz, Klimov |
| 44 | 1992 | 4 | Rominger, Nijdam, Ruiz, Montoya |
| 45 | 1996 | 4 | Zülle, Jalabert, Baldato, Conte |
| 46 | 2003 | 4 | Nozal, Gonzalez De Galdeano, Rodríguez, Heras |
| 47 | 2009 | 4 | Greipel, Cancellara, Evans, Valverde |
| 48 | 2012 | 4 | Valverde, Contador, Castroviejo, Rodríguez |
| 49 | 1935 | 3 | Dignef, Escuriet, Deloor |
| 50 | 1941 | 3 | Rodríguez, Trueba, Berrendero |
| 51 | 1947 | 3 | Dijck, Costa, Rodríguez |
| 52 | 1962 | 3 | Altig, Elliott, Barrutia |
| 53 | 1965 | 3 | Poulidor, Looy, Wolfshohl |
| 54 | 1973 | 3 | Pesarrodona, Merckx, Karstens |
| 55 | 1984 | 3 | Caritoux, Delgado, Moser |
| 56 | 1991 | 3 | Mauri, Fuerte, Diaz |
| 57 | 1995 | 3 | Olano, Jalabert, Pianegonda |
| 58 | 2005 | 3 | Menchov, Heras, McGee |
| 59 | 2017 | 3 | Froome, Lampaert, Dennis |
| 60 | 1936 | 2 | Huts, Deloor |
| 61 | 1945 | 2 | Berrendero, Rodríguez |
| 62 | 1950 | 2 | Braeckeveldt, Rodríguez |
| 63 | 1956 | 2 | Conterno, Steenbergen |
| 64 | 1963 | 2 | Anquetil, Barrutia |
| 65 | 1978 | 2 | Hinault, Haute |
| 66 | 1979 | 2 | Levavasseur, Zoetemelk |
| 67 | 1980 | 2 | Rupérez, Visentini |
| 68 | 1981 | 2 | Clère, Battaglin |
| 69 | 1993 | 2 | Rominger, Zülle |
| 70 | 1942 | 1 | Berrendero |
| 71 | 1977 | 1 | Maertens |
| 72 | 1994 | 1 | Rominger |
