Biggest races where rider never competed
Major races where E O'Brien never competed in.
| # | Race | Class |
|---|---|---|
| 1 | Tour de France | 2.PT |
| 2 | Milano-Sanremo | 1.HC |
| 3 | World Championships ME - Road Race | WC |
| 4 | Giro d'Italia | 2.PT |
| 5 | Paris - Roubaix | 1.HC |
| 6 | Giro di Lombardia | 1.HC |
| 7 | Paris - Nice | 2.PT |
| 8 | Liège - Bastogne - Liège | 1.HC |
| 9 | Vuelta a España | 2.PT |
| 10 | Ronde van Vlaanderen / Tour des Flandres ME | PT |
| 11 | La Flèche Wallonne | 1.HC |
| 12 | Paris - Tours | 1.HC |
| 13 | Gent - Wevelgem | PT |
| 14 | Tour de Suisse | 2.PT |
| 15 | Amstel Gold Race | 1.HC |
| 16 | Critérium du Dauphiné Libéré | PT |
| 17 | Tirreno-Adriatico | 2.PT |
| 18 | Paris-Bruxelles | 1.HC |
| 19 | Volta Ciclista a Catalunya | 2.PT |
| 20 | Omloop Het Nieuwsblad ME | 1.HC |
| 21 | Vuelta Ciclista al País Vasco | 2.UWT |
| 22 | Clasica Ciclista San Sebastian | PT |
| 23 | Tour de Romandie | 2.PT |
| 24 | Meisterschaft von Zürich | 1.PT2 |
| 25 | Giro dell'Emilia | 1.HC |