| 1 | 2021-02-28 | Kuurne-Brussel-Kuurne | 1.Pro |
| 2 | 2021-03-03 | Trofeo Laigueglia | 1.Pro |
| 3 | 2021-03-03 | Trofej Umag - Umag Trophy | 1.2 |
| 4 | 2021-03-06 | Strade Bianche | 1.UWT |
| 5 | 2021-03-07 | GP Industria & Artigianato | 1.Pro |
| 6 | 2021-03-11 | Istarsko Proljeće - Istrian Spring Trophy | 2.2 |
| 7 | 2021-03-17 | Danilith Nokere Koerse ME | 1.Pro |
| 8 | 2021-03-19 | Bredene Koksijde Classic | 1.Pro |
| 9 | 2021-03-21 | Per Sempre "Alfredo" | 1.1 |
| 10 | 2021-03-23 | Settimana Internazionale Coppi e Bartali | 2.1 |
| 11 | 2021-03-24 | Oxyclean Classic Brugge-De Panne ME | 1.UWT |
| 12 | 2021-03-26 | E3 Saxo Bank Classic | 1.UWT |
| 13 | 2021-05-12 | Tour de Hongrie | 2.1 |
| 14 | 2021-05-14 | Tour d'Eure-et-Loir | 2.2 |
| 15 | 2021-05-19 | Alpes Isère Tour | 2.2 |
| 16 | 2021-05-24 | Mercan'Tour Classic Alpes-Maritimes | 1.1 |
| 17 | 2021-06-04 | Grosser Preis des Kantons Aargau | 1.1 |
| 18 | 2021-06-09 | Baloise Belgium Tour | 2.Pro |
| 19 | 2021-06-15 | Adriatica Ionica Race / Sulle Rotte della Serenissima | 2.1 |
| 20 | 2021-06-24 | Giro dell'Appennino | 1.1 |
| 21 | 2021-06-27 | Axion SWISS Bank Gran Premio Città di Lugano | 1.1 |
| 22 | 2021-07-03 | Sibiu Cycling Tour | 2.1 |
| 23 | 2021-07-14 | Settimana Ciclistica Italiana | 2.1 |
| 24 | 2021-08-05 | Sazka Tour | 2.1 |
| 25 | 2021-08-10 | PostNord Danmark Rundt - Tour of Denmark | 2.Pro |
| 26 | 2021-08-17 | Tour du Limousin - Nouvelle Aquitaine | 2.1 |
| 27 | 2021-08-26 | Druivenkoers - Overijse | 1.1 |
| 28 | 2021-08-28 | Brussels Cycling Classic | 1.Pro |
| 29 | 2021-09-03 | Classic Grand Besançon Doubs | 1.1 |
| 30 | 2021-09-04 | Tour du Jura Cycliste | 1.1 |
| 31 | 2021-09-05 | Tour du Doubs | 1.1 |
| 32 | 2021-09-12 | GP de Fourmies / La Voix du Nord | 1.Pro |
| 33 | 2021-09-14 | Škoda-Tour de Luxembourg | 2.Pro |
| 34 | 2021-09-15 | Giro della Toscana - Memorial Alfredo Martini | 1.1 |
| 35 | 2021-09-16 | Coppa Sabatini - Gran Premio città di Peccioli | 1.Pro |
| 36 | 2021-09-18 | Memorial Marco Pantani | 1.1 |
| 37 | 2021-09-19 | Trofeo Matteotti | 1.1 |
| 38 | 2021-09-28 | Giro di Sicilia - Tour of Sicily | 2.1 |
| 39 | 2021-10-02 | Giro dell'Emilia | 1.Pro |
| 40 | 2021-10-04 | Coppa Bernocchi - GP BPM | 1.Pro |
| 41 | 2021-10-05 | Tre Valli Varesine | 1.Pro |
| 42 | 2021-10-06 | Milano - Torino | 1.Pro |
| 43 | 2021-10-07 | Circuit des Ardennes International | 2.2 |
| 44 | 2021-10-07 | Gran Piemonte | 1.Pro |
| 45 | 2021-10-09 | Il Lombardia | 1.UWT |
| 46 | 2021-10-11 | Coppa Agostoni - Giro delle Brianze | 1.1 |
| 47 | 2021-10-13 | Giro del Veneto | 1.1 |
| 48 | 2021-10-17 | Veneto Classic | 1.1 |